Related Experiment Video
Updated: Oct 19, 2025

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments
Published on: January 20, 2022
Electrospray Ionization Ion Mobility Mass Spectrometry
Katie M Kohoutek1, Peter de B Harrington1
1Department of Chemistry and Biochemistry, Ohio University, Athens, OH, USA.
Abstract:
Electrospray ionization ion mobility mass spectrometry (ESI-IMS-MS) is a rapidly progressing analytical technique for the examination of complex compounds in the gas phase. ESI-IMS-MS separates isomers, provides structural information, and quantitatively identifies peptides, lipids, carbohydrates, polymers, and metabolites in biological samples. ESI-IMS-MS has pharmaceutical, environmental, and manufacturing applications quickly characterizing drugs, petroleum products, and metal macromolecules. This review provides the history of ESI-IMS-MS development and applications to date.
More Related Videos
Related Concept Videos
Electrospray Ionization (ESI) Mass Spectrometry
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...
Mass Spectrometry: Overview
Chemical Ionization (CI) Mass Spectrometry
Mass Spectrometers
Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview
Matrix-Assisted Laser Desorption Ionization (MALDI)
The analyte of interest, a biomolecule or a mixture of biomolecules, is mixed with a suitable matrix material. The...

