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Total and Unbound Doravirine Concentrations and Viral Suppression in CSF

Juan Tiraboschi1, Sofia Scévola1, Sujan Dilly Penchala2

  • 1HIV and STI Unit, Infectious Disease Service, Hospital Universitari de Bellvitge-IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|September 22, 2021
PubMed

Keywords:
CNSCSFDoravirineHIVconcentrationsunbound

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Drug Concentrations: Measurements01:23

Drug Concentrations: Measurements

Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
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