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Aortic aneurysm evaluation by scanning acoustic microscopy and Raman spectroscopy
Bukem Tanoren1, Ugur Parlatan2, Melita Parlak2
1Acibadem University, Department of Natural Sciences, Istanbul, Turkey. bukem.tanoren@acibadem.edu.tr.
Analytical Methods : Advancing Methods and Applications
|September 22, 2021
Summary
This study explored scanning acoustic microscopy (SAM) and Raman spectroscopy (RS) for characterizing aortic aneurysm. Combining these techniques offers micrometer resolution for better surgical assessment and prevention of new aneurysm formation.
Area of Science:
- Biomedical Engineering
- Materials Science
- Medical Diagnostics
Background:
- Aortic aneurysm involves significant changes in aortic wall elasticity due to elastin and collagen degradation.
- Accurate characterization of dilated aortic segments is crucial for effective surgical intervention.
Purpose of the Study:
- To assess the feasibility of scanning acoustic microscopy (SAM) and Raman spectroscopy (RS) for characterizing aortic aneurysm.
- To evaluate the potential of combining SAM and RS for improved diagnostic capabilities in aortic aneurysm cases.
Main Methods:
- Scanning acoustic microscopy (SAM) was used to measure acoustic impedance variations in 18 patient aorta samples.
- Raman spectroscopy (RS) analyzed chemical variations, focusing on elastin and collagen peaks, using k-means classification.
- Both techniques were applied to characterize dilated aortic segments from male and female patients.
Main Results:
- SAM successfully identified variations in acoustic properties within the aorta.
- RS, coupled with k-means classification, effectively differentiated disease states based on biochemical changes.
- The study demonstrated the potential of these techniques in providing micrometer-resolution data.
Conclusions:
- Combining SAM and RS offers a promising approach for detailed characterization of the aorta in patients with aortic aneurysm.
- This integrated method can aid in surgical planning by identifying all affected segments, potentially reducing the risk of recurrent aneurysm formation.
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