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Arterial Stiffness and Left Ventricular Myocardial Function in Children with a Well-Functioning Bicuspid Aortic Valve

Pelin Kosger1, Tugcem Akin2, Hikmet Kiztanir1

  • 1Eskisehir Osmangazi University, Faculty of Medicine, Department of Pediatric Cardiology, Eskisehir - Turquia.

Arquivos Brasileiros De Cardiologia
|September 22, 2021
PubMed

Insights

Children with bicuspid aortic valve show similar arterial stiffness to healthy peers. However, ascending aorta diameter predicts left ventricular function, suggesting arterial stiffness is not a major risk in pediatric patients without significant aortic dilation.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Research
  • Congenital Heart Disease

Background:

  • Bicuspid aortic valve (BAV) is associated with aortopathy and myocardial remodeling.
  • Arterial stiffness may be elevated in children with BAV.

Purpose of the Study:

  • To evaluate arterial stiffness and left ventricular myocardial function in children with BAV.
  • To determine if BAV affects cardiovascular parameters in pediatric patients.

Main Methods:

  • Case-control study comparing 44 children with BAV to 41 healthy controls.
  • Assessed aortic dimensions, left ventricular function (tissue Doppler imaging), and arterial stiffness (oscillometric pulse wave analysis).

Main Results:

  • Children with BAV had higher left ventricular mass index, ascending aorta diameter, and myocardial performance index.
  • Ascending aorta diameter correlated with myocardial performance index and was an independent predictor of left ventricular function.
  • Arterial stiffness measures (augmentation index, pulse wave velocity) were similar between groups.

Conclusions:

  • Well-functioning BAV in children is not associated with increased arterial stiffness compared to healthy peers.
  • Ascending aorta diameter is a key factor influencing left ventricular function in pediatric BAV.
  • Arterial stiffness is unlikely a significant risk factor in pediatric BAV patients without significant aortic dilation.
Abstract

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