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Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
Marcello Henrique Araújo da Silva1, João Henrique Duque Estrada2, Bianca Martins Gregório3
1MSc. Urogenital Research Unit - Universidade do Estado do Rio de Janeiro - Rio de Janeiro (RJ), Brazil.
Acta Cirurgica Brasileira
|September 22, 2021
Summary
Finasteride and dutasteride treatments caused kidney damage in rats, increasing serum urea and creatinine levels. Dutasteride resulted in more severe renal modifications than finasteride.
Area of Science:
- Pharmacology
- Nephrology
- Toxicology
Background:
- 5-alpha-reductase inhibitors (5-ARIs) like finasteride and dutasteride are used to treat conditions such as benign prostatic hyperplasia.
- Potential side effects of these drugs on organ systems require thorough investigation.
Purpose of the Study:
- To evaluate the renal effects of dutasteride and finasteride in a rat model.
- To compare the severity of kidney modifications induced by these two 5-ARIs.
Main Methods:
- Male rats were administered dutasteride (0.5 mg/kg/day) or finasteride (5 mg/kg/day) via gavage for 40 days.
- Blood samples were analyzed for urea and creatinine levels.
- Kidney morphology was assessed using stereological methods.
Main Results:
- Both finasteride and dutasteride groups exhibited elevated serum urea and creatinine levels compared to controls.
- Kidney weight, volume, cortical volume, and glomerular parameters (volumetric density, mean volume) were reduced in both treatment groups.
- The number of glomeruli per kidney decreased by 26.8% with finasteride and 51.6% with dutasteride.
Conclusions:
- Finasteride and dutasteride induce morphological and functional renal damage in rats.
- Dutasteride treatment led to more pronounced renal modifications than finasteride treatment.
