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Updated: Aug 15, 2026

Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System
Published on: June 11, 2020
Abstract:
It appears obvious that in evaluating gross mortality and morbidity, clinical statistics are insufficient to demonstrate which form of a myocardial protective measure is safest. Previous studies indicate that significant ischemic injury may not be detectable by routine measurements of contractility. Only microscopic examination of the heart at a later period will allow detection of the patchy ischemic injury. In patients, loss of cardiac reserve as measured by postoperative catheterization, particularly compliance studies, and stress testing may be the final clinical arbiter of this controversy.

