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[Eosinophilic, solid, and cystic renal cell carcinoma (ESC-RCC)]
Arndt Hartmann1, Abbas Agaimy2
1Institut für Pathologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstraße 8-10, 91054, Erlangen, Deutschland. arndt.hartmann@uk-erlangen.de.
Eosinophilic, solid, and cystic renal cell carcinoma (ESC-RCC) is a distinct kidney tumor primarily affecting women, often linked to TSC mutations. While typically indolent, distinguishing it from other eosinophilic tumors is crucial.
Area of Science:
- Nephrology
- Oncology
- Pathology
Background:
- Eosinophilic, solid, and cystic renal cell carcinoma (ESC-RCC) is a distinct epithelial renal tumor.
- It predominantly affects women and is often associated with sporadic (somatic) or germline TSC mutations.
Purpose of the Study:
- To define the clinicopathological and molecular features of ESC-RCC.
- To differentiate ESC-RCC from other eosinophilic renal tumors.
- To explore the potential spectrum of TSC/mTOR-related neoplasms.
Main Methods:
- Clinicopathological analysis of ESC-RCC cases.
- Immunohistochemical profiling (CD117-/CK7-/CK20+).
- Review of molecular alterations, particularly TSC and mTOR pathway involvement.
Main Results:
- ESC-RCC presents as small, well-circumscribed lesions with cystic spaces.
- Characteristic immunohistochemical profile: CD117-/CK7-/CK20+.
- Tumors are generally indolent, with rare aggressive cases responding to mTOR inhibitors.
Conclusions:
- ESC-RCC is a unique entity with characteristic molecular (TSC/mTOR) and pathological features.
- Distinguishing ESC-RCC from other eosinophilic renal tumors (e.g., EVT, LOT) is essential.
- Further research is needed to clarify if ESC-RCC, EVT, and LOT are distinct entities or variants within a spectrum of TSC/mTOR-related neoplasms.
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