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Updated: Oct 19, 2025
Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
The relation between left ventricular systolic function parameters and preceding or prepreceding beat-to-beat
Serkan Dilmen1, Mehmet Uzun2, Tufan Çınar3
1Department of Cardiology, Manisa Demirci State Hospital, Manisa, Turkey.
Insights
New parameters analyzing left ventricular (LV) systolic function and preceding beat intervals (RR1) show promise for detecting heart failure with reduced ejection fraction (HFrEF) in patients with atrial fibrillation (AF). These novel metrics may aid in evaluating systolic dysfunction in this population.
Area of Science:
- Cardiology
- Cardiac Electrophysiology
- Heart Failure Research
Background:
- Atrial fibrillation (AF) complicates the assessment of systolic function in heart failure with reduced ejection fraction (HFrEF).
- Understanding the relationship between cardiac cycle length variability and left ventricular (LV) systolic performance is crucial for HFrEF management.
Purpose of the Study:
- To investigate the association between LV systolic parameters and preceding beat-to-beat intervals (RR1 and RR2).
- To determine if this relationship differs in HFrEF patients with AF.
- To identify novel parameters predictive of HFrEF in the presence of AF.
Main Methods:
- Linear regression analysis was used to examine the relationship between LV systolic parameters (VLVOT, LAVPD, Lateral S') and preceding beat-to-beat intervals (RR1, RR2).
- Key regression parameters (slope, constant, r2) were derived.
- Kendall rank correlation analysis assessed the correlation of these parameters with left ventricular ejection fraction (LVEF).
Main Results:
- In HFrEF patients, regression analysis between RR1 and LV systolic parameters (VLVOT, LAVPD, Lateral S') showed higher slopes and r2 values, and lower constants.
- Regression parameters (slope, constant, r2) between RR1 and VLVOT or Lateral S' significantly correlated with LVEF.
- Specific parameters (r2 of VLVOT-RR1, slope of VLVOT-RR1, slope of Lateral S'-RR1) were predictive of HFrEF.
Conclusions:
- Novel parameters derived from linear regression analysis of LV systolic function and RR1 intervals (not RR2) may be valuable for evaluating systolic heart failure in AF patients.
- These findings suggest potential for future research into the pathophysiology and prognosis of heart conditions in patients with AF.
Abstract:
We aimed at investigating the relation between left ventricle (LV) systolic parameters and beat-to-beat distances and also whether this relation is different in heart failure with reduced ejection fraction (HFrEF) patients with atrial fibrillation (AF). The relation between peak velocity in left ventricular outflow (VLVOT), left atrioventricular plane displacement (LAVPD) or peak systolic tissue Doppler velocity of lateral mitral annulus (Lateral S') and preceding beat-to-beat distance (RR1) or prepreceding beat-to-beat distance (RR2) were analyzed by linear regression analysis. From this analysis, three parameters were obtained: slope of regression line, constant of regression line, and square of regression coefficient (r2) of linear relation. In the group with HFrEF, the slope and r2 values of the regression line showing the relationship between the RR1 interval and VLVOT, LAVPD, and Lateral S' values were higher and the constants were lower. In the Kendall rank correlation analysis, the slope, constant, and r2 values of the regression analysis between RR1 interval and VLVOT or Lateral S' were in significant correlation with LVEF. The r2 of VLVOT-RR1 analysis, slope of this analysis, and slope of Lateral S'-RR1 regression line values were mostly predictive for detecting HFrEF. It was concluded that the novel parameters obtained by linear regression analysis between LV systolic function parameters and RR1 interval, but not RR2, might be beneficial for evaluating systolic heart failure in patients with AF. They might have potential for future research about the physiopathology of heart and prognosis in patient with AF.
