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Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis
Published on: June 20, 2012
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Parallel cognitive processing streams in human prefrontal cortex: Parsing areal-level brain network for response
Takahiro Osada1, Akitoshi Ogawa1, Akimitsu Suda2
1Department of Neurophysiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Cell Reports
|September 22, 2021
Summary
This study reveals two parallel brain processing streams for response inhibition. These streams, involving specific cortical areas, work together to control behavior.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Cognitive Psychology
Background:
- Adaptive behavior relies on multiple cognitive processes.
- The temporal organization of cortical processing streams for behavior remains unclear.
Purpose of the Study:
- To identify cortical processing streams for response inhibition.
- To investigate the relationships and information flow between these processing streams.
Main Methods:
- Functional magnetic resonance imaging (fMRI) was used to observe brain activity.
- Time-resolved single-pulse transcranial magnetic stimulation (TMS) was employed to disrupt cortical areas.
- Repetitive TMS was used to suppress specific brain regions, followed by single-pulse TMS.
Main Results:
- Three distinct critical timings of disruption were identified in essential cortical areas within two cerebrocortical networks.
- Information flow was observed from the ventral posterior inferior frontal cortex (vpIFC) to the presupplementary motor area (preSMA).
- No causal information flow was detected from vpIFC to the dorsal posterior inferior frontal cortex (dpIFC).
Conclusions:
- Two parallel processing streams, (vpIFC-preSMA) and (dpIFC-intraparietal sulcus), operate concurrently during response inhibition.
- These findings elucidate the neural mechanisms underlying inhibitory control and adaptive behavior.
Keywords:
areal parcellation response inhibitioncerebrocortical networkfMRIfrontal cortexneuroimagingnoninvasive brain stimulationstop-signal tasktranscranial magnetic stimulationMore Related Videos
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