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Updated: Oct 19, 2025

Extraction of Extracellular Vesicles from Whole Tissue
Published on: February 7, 2019
The functions and potential roles of extracellular vesicle noncoding RNAs in gynecological malignancies
Lulu Si1,2, Jing Bai1,2, Hanlin Fu1,2
1Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Abstract:
Extracellular vesicles (EVs) are small membranous vesicles secreted by multiple kinds of cells and are widely present in human body fluids. EVs containing various constituents can transfer functional molecules from donor cells to recipient cells, thereby mediating intercellular communication. Noncoding RNAs (ncRNAs) are a type of RNA transcript with limited protein-coding capacity, that have been confirmed to be enriched in EVs in recent years. EV ncRNAs have become a hot topic because of their crucial regulating effect in disease progression, especially in cancer development. In this review, we summarized the biological functions of EV ncRNAs in the occurrence and progression of gynecological malignancies. In addition, we reviewed their potential applications in the diagnosis and treatment of gynecological malignancies.
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