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In vitro study of the antibiotic activity of diterpenes
A M Giesbrecht1, S C Davino, R C Barbosa
1Departamento de Farmacologia, Universidade de São Paulo, Brasil.
Abstract:
The antibiotic activity of 16 diterpenes and of 2 phenanthrene derivatives of diterpene origin, isolated from Brazilian plants was investigated against bacteria, yeasts, dermatophytes and aflatoxin-producing fungi. Eight of the compounds were completely inactive. None showed inhibitory activity against the Gram-negative bacteria assayed or against the Aspergillus species. The phenanthrene derivatives, chemically very similar to phytoalexins isolated from orchids, were especially active.