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Non-bacterial thrombotic endocarditis with cryptogenic stroke

Hirokazu Toyoshima1, Bun Nakanura2, Motoaki Tanigawa3

  • 1Department of Infectious Diseases Japanese Red Cross Ise Hospital Ise Japan.

Clinical Case Reports
|September 23, 2021
PubMed

Insights

Diagnosing non-bacterial thrombotic endocarditis relies on negative blood cultures and pathological results. Treatment for this condition requires personalized plans, often involving anticoagulation or surgery, depending on the patient

Area of Science:

  • Cardiology
  • Pathology

Background:

  • Non-bacterial thrombotic endocarditis (NBTE) is a rare condition often associated with malignancy or chronic illness.
  • Diagnosis can be challenging due to negative blood cultures, necessitating reliance on clinical and pathological findings.

Purpose of the Study:

  • To highlight the diagnostic utility of pathological findings in NBTE.
  • To discuss individualized treatment strategies for NBTE based on underlying conditions.

Main Methods:

  • Review of clinical cases and pathological examinations of patients with NBTE.
  • Analysis of treatment outcomes based on patient comorbidities and interventions.

Main Results:

  • Negative blood cultures are common in NBTE.
  • Pathological examination of cardiac valves reveals characteristic sterile vegetations.
  • Treatment decisions, including anticoagulation and surgical intervention, are tailored to individual patient factors.

Conclusions:

  • Pathological findings are crucial for diagnosing NBTE when blood cultures are negative.
  • Personalized treatment approaches are essential for managing NBTE effectively, considering the patient's overall health status and underlying diseases.

Keywords:
cryptogenic strokelifelong anticoagulationnon‐bacterial thrombotic endocarditissurgerytransesophageal echocardiography

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