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Low-intensity extracorporeal shockwave therapy for erectile dysfunction.

Onder Canguven1, Kareim Khalafalla1, Abdulla Al Ansari1

  • 1Urology Department, Hamad General Hospital, Doha, Qatar.

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|September 23, 2021
PubMed
Summary

Low-intensity extracorporeal shockwave therapy (LI-ESWT) shows potential for erectile dysfunction (ED) in lab settings, but clinical trial results remain controversial. More high-quality research is needed to confirm its effectiveness for ED treatment in humans.

Keywords:
Low-intensity extracorporeal shockwave therapyerectile dysfunctionerectionmale

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Area of Science:

  • Urology
  • Andrology
  • Regenerative Medicine

Background:

  • Erectile dysfunction (ED) affects a significant number of men globally.
  • Current ED treatments have limitations, necessitating novel therapeutic approaches.
  • Low-intensity extracorporeal shockwave therapy (LI-ESWT) has emerged as a potential non-invasive treatment for ED.

Purpose of the Study:

  • To systematically review the existing clinical evidence on the effectiveness of LI-ESWT for treating ED.
  • To analyze the outcomes of randomized clinical trials (RCTs) investigating LI-ESWT in ED patients.

Main Methods:

  • A systematic literature search was conducted using MeSH terms 'low intensity extracorporeal shock wave therapy' and 'erectile dysfunction'.
  • Publications from January 2010 to December 2020 were screened in PubMed and Web of Science databases.
  • Eleven prospective randomized clinical trials involving 920 male patients were included in the analysis.

Main Results:

  • A total of 11 RCTs with 920 male patients (aged 18-80 years, ED symptoms ≥3 months) were analyzed.
  • Statistically significant improvement in erectile function was observed in 348 patients (37.8%) post-LI-ESWT.
  • No statistically significant improvement was noted in 572 patients (62.2%).

Conclusions:

  • LI-ESWT demonstrates a role in ED treatment in preclinical/laboratory settings.
  • The clinical effectiveness of LI-ESWT for ED in human trials remains controversial and inconclusive.
  • Further high-quality clinical studies are required to ascertain the true therapeutic potential of LI-ESWT for ED.