Related Experiment Video
Updated: Oct 19, 2025

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
Caloric Restriction May Help Delay the Onset of Frailty and Support Frailty Management
1Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.
Abstract:
Frailty is an age-related clinical syndrome that may increase the risk of falls, disability, hospitalization, and death in older adults. Delaying the progression of frailty helps improve the quality of life in older adults. Caloric restriction (CR) may extend lifespan and reduce the risk of age-related diseases. However, few studies have explored the relationship between CR and frailty. In this review, we focused on the impact of CR on frailty and aimed to identify potential associated mechanisms. Although CR may help prevent frailty, further studies are required to determine the underlying mechanisms and specific CR regimens suitable for use in humans.
Related Concept Videos
Chronic Kidney Disease III: Interprofessional Care
Pharmacodynamics in Geriatric Patients: Effects of Age
Metabolic States of the Body: Fasting and Starvation
Regulation of Metabolism
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Regulation of Food Intake

