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[Vascular inflammation underlies the development of atherothrombotic stroke]
A V Romanenko1, I P Amelina1, E Yu Solovyeva1
1Pirogov Russian National Research Medical University, Moscow, Russia.
Insights
Atherothrombotic stroke stems from inflammation and atherosclerosis in brain arteries. Mexidol shows promise in managing brain ischemia by normalizing hemodynamics and enhancing neuroplasticity.
Area of Science:
- Neuroscience
- Cardiovascular Medicine
- Pharmacology
Background:
- Atherothrombotic stroke, a common ischemic cerebral disorder, arises from atherosclerosis in major cerebral arteries.
- The atherosclerotic process involves vascular wall inflammation, endothelial dysfunction, and oxidative stress, impacting the blood-brain barrier.
- These factors contribute to clinical symptoms and acute vascular events.
Purpose of the Study:
- To explore the molecular underpinnings of cerebral vessel dysfunction in atherothrombotic stroke.
- To identify pathogenetically justified therapeutic strategies for brain ischemia.
- To evaluate the potential of 2-ethyl-6-methyl-3-oxypyridine-succinate (mexidol) in managing brain ischemia.
Main Methods:
- Review of recent studies on the inflammatory basis of atherosclerosis.
- Analysis of molecular mechanisms in cerebral vascular damage.
- Assessment of mexidol's potential role in complex drug therapy.
Main Results:
- Atherosclerosis initiation is linked to inflammatory processes in the vascular wall.
- Endothelial dysfunction, oxidative stress, and protein redistribution affect the blood-brain barrier.
- Mexidol is proposed as a pathogenetically justified agent for brain ischemia therapy.
Conclusions:
- Understanding molecular components is key to modern therapy for cerebral vascular disorders.
- Therapeutic strategies should normalize hemodynamics and incorporate neuroplasticity mechanisms.
- Mexidol presents a potential option for integrated treatment of brain ischemia.
Abstract:
Atherothrombotic stroke is the one of the most common subtypes of ischemic cerebral circulatory disorders, the cause of which is atherosclerosis of the major arteries of the brain or their branches. The results of recent studies have shown that the atherosclerotic process is based on an inflammatory process in the vascular wall that leads to the initiation of atherosclerosis, endothelial dysfunction, oxidative stress, and the redistribution of various protein components in the blood-brain barrier. As a result, the progression of the described conditions leads to the manifestation of clinical symptoms and the formation of an acute vascular event. Understanding of the molecular components underlying functional disorders and damages of the cerebral vessels gives the key to modern therapy strategies. It is forming the foundation for the adequate, pathogenetically reasonable drug correction. For such patients, it should be aimed at the normalization of cerebral and central hemodynamics and incorporate the mechanisms of neuroplasticity. The drug 2-ethyl-6-methyl-3-oxypyridine-succinate (mexidol) can be considered as one of the pathogenetically justified agents in complex drug therapy of brain ischemia.
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