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Updated: Oct 19, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Recent advances in rhodium-catalyzed C(sp2)-H (hetero)arylation
Zixian Yang1, Jin-Tao Yu1, Changduo Pan2
1School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, Changzhou University, Changzhou 213164, P. R. China. yujintao@cczu.edu.cn.
Abstract:
Arylation is a common behaviour in organic synthesis for the construction of complex structures, especially the biaryls. Among those reported arylation procedures, transition-metal-catalyzed direct C(sp2)-H arylation has been rapidly developed in recent decades and has become a reliable alternative to traditional cross-coupling procedures using organometallic reagents. Great achievements in rhodium-catalyzed C(sp2)-H arylation have been witnessed during the last decade. Aryl halides, simple arenes, aryl boronic acids, arylsilanes, aryl aldehyde, aryl carboxylic acid, diazides, etc. were successfully utilized as arylating reagents under rhodium-catalyzed conditions. In this review, recent achievements in rhodium-catalyzed arylations through C(sp2)-H bond activation were summarized together with the mechanism discussions.
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