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Interactions between probiotic and oral pathogenic strains.

Noémi N Gönczi1, Orsolya Strang2, Zoltán Bagi2

  • 1Department of Biotechnology, University of Szeged, Közép fasor 52., Szeged, 6726, Hungary. nikolett.noemi.gonczi@gmail.com.

Biologia Futura
|September 23, 2021
PubMed
Summary

Oral dysbiosis, linked to conditions like gingivitis, can be combatted by probiotics. Specific probiotic strains demonstrated the ability to inhibit the growth of common oral pathogens, offering potential therapeutic solutions.

Keywords:
BacteriocinDysbiosisModified agar diffusion testOral diseases

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Area of Science:

  • Microbiology
  • Oral Health
  • Bacteriology

Background:

  • The adult oral cavity hosts over 6 billion microorganisms, and disruptions (oral dysbiosis) can lead to serious health issues like caries, halitosis, gingivitis, and periodontitis.
  • Oral dysbiosis significantly impacts patient quality of life, with treatments often being invasive, costly, and irreversible, such as tooth loss.

Purpose of the Study:

  • To investigate the interactions between specific oral pathogenic bacteria and probiotic strains.
  • To identify probiotic candidates capable of inhibiting the growth of oral pathogens for potential therapeutic applications.

Main Methods:

  • Utilized a modified agar diffusion method to assess the inhibitory effects of probiotic strains against pathogenic oral bacteria.
  • Tested 8 common oral pathogens (e.g., Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus mutans) against 8 probiotic strains (e.g., Lactobacillus spp., Bifidobacterium thermophilum, Streptococcus dentisani).

Main Results:

  • At least five probiotic strains demonstrated the ability to inhibit the growth of every tested pathogenic bacterium.
  • Evidence of successful bacteriocin production, leading to growth inhibition of oral pathogens, was observed.

Conclusions:

  • Probiotic bacteria, specifically certain Lactobacillus and Streptococcus dentisani strains, show significant potential in controlling oral pathogenic bacteria.
  • These findings support the development of novel probiotic-based therapies to manage oral dysbiosis and related conditions.