Endoscopic Approaches to Obesity Management.

Area of Science:

• Endoscopic Bariatric and Metabolic Therapies
• Minimally Invasive Weight Management

Background:

• Endoscopic therapies have evolved from post-surgical weight regain treatment to primary weight loss interventions.
• Initial gastric devices focused on volume restriction for early satiety and reduced caloric intake.

Purpose of the Study:

• To review current and emerging endoscopic interventions for weight loss and obesity-related comorbidities.
• To explore the potential of combination therapy using both gastric and small bowel endoscopic approaches.

Main Methods:

• Review of gastric interventions: intragastric balloons, aspiration therapy, endoscopic suturing, and plication.
• Review of small bowel interventions: endoluminal bypass liners, duodenal mucosal resurfacing, and incisionless anastomosis devices.

Main Results:

• Gastric interventions primarily induce weight loss through volume restriction and satiety.
• Small bowel interventions are emerging for weight loss and significant comorbidity management.
• Combination therapy presents a promising future strategy for enhanced weight loss and metabolic improvement.

Conclusions:

• Endoscopic bariatric and metabolic therapies provide viable alternatives to pharmacologic and surgical treatments.
• The integration of gastric and small bowel endoscopic interventions holds significant potential for comprehensive obesity management.