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RIFM fragrance ingredient safety assessment, cis-3-hexenyl tiglate, CAS Registry Number 67883-79-8
Summary
This safety assessment confirms cis-3-Hexenyl tiglate is safe for use, showing no genotoxicity, reproductive toxicity, or skin sensitization concerns. Environmental evaluations also indicate it is not Persistent, Bioaccumulative, and Toxic (PBT).
Area of Science:
- Fragrance ingredient safety assessment
- Toxicology
- Environmental risk evaluation
Background:
- cis-3-Hexenyl tiglate is a fragrance ingredient requiring comprehensive safety evaluation.
- Existing data and read-across approaches are utilized to assess potential toxicological and environmental risks.
Purpose of the Study:
- To evaluate the safety of cis-3-Hexenyl tiglate across multiple toxicological endpoints.
- To determine the genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety of cis-3-Hexenyl tiglate.
Main Methods:
- Genotoxicity assessed via read-across from structural analogs.
- Repeated dose, reproductive, and local respiratory toxicity evaluated using the Threshold for Toxicological Concern (TTC) for Cramer Class I materials.
- Skin sensitization determined using data from a relevant analog to establish a No Expected Sensitization Induction Level (NESIL).
- Phototoxicity/photoallergenicity assessed using ultraviolet/visible (UV/Vis) spectra.
- Environmental safety evaluated against International Fragrance Association (IFRA) Environmental Standards, including assessment of Persistent, Bioaccumulative, and Toxic (PBT) properties and risk quotients (PEC/PNEC).
Main Results:
- cis-3-Hexenyl tiglate is not expected to be genotoxic based on read-across data.
- Exposure levels are below the TTC for repeated dose, reproductive, and local respiratory toxicity.
- A NESIL of 1100 μg/cm² was established for skin sensitization.
- cis-3-Hexenyl tiglate is not expected to be phototoxic or photoallergenic.
- The material is not PBT and has risk quotients <1 in Europe and North America, indicating environmental safety.
Conclusions:
- The available data support the safe use of cis-3-Hexenyl tiglate as described in this assessment.
- No significant toxicological concerns were identified for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, or skin sensitization.
- Environmental risk assessment indicates cis-3-Hexenyl tiglate poses no unacceptable risk to the environment.
