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Complement factor H: a guardian within?

Idris Boudhabhay1, Lubka T Roumenina2

  • 1Service de Néphrologie et Transplantation Rénale, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université de Paris, Paris, France; Centre de Recherche des Cordeliers, Institut national de la santé et de la recherche médicale (INSERM), Sorbonne Université, Université de Paris, Team Inflammation, Complement and Cancer, Paris, France.

Kidney International
|September 24, 2021
PubMed

The glomerular endothelium produces the key complement regulator factor H (FH), but its role in the endothelial cells protection and functional integrity is unclear. In this edition of Kidney International, Mahajan et al. demonstrate that the endothelial-intrinsic FH is important for the cytoskeletal architecture, monolayer integrity, proliferation control, metabolism, and inflammatory signaling regulation. These findings place the endothelium-derived FH in the center of the pathological process of diseases, characterized with FH genetic abnormalities.

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