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Is Early COVID-19 in Kidney Transplant Recipients Concerning Enough to Halt Transplantation? A Multicenter

Hari Shankar Meshram1, Vivek B Kute1, Himanshu V Patel1

  • 1Department of Nephrology, Institute of Kidney Diseases and Research Centre, Dr. H. L. Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat, India.

Transplantation Proceedings
|September 24, 2021
PubMed

Insights

Early coronavirus disease 2019 (COVID-19) in kidney transplant recipients (KTR) showed a 2.6% incidence and favorable outcomes. Waitlisted patients faced a higher burden of COVID-19, indicating transplantation can resume safely.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Transplantation Immunology

Background:

  • Limited data exists on the incidence and outcomes of early coronavirus disease 2019 (COVID-19) in kidney transplantation recipients (KTR).
  • Understanding COVID-19's impact on KTR is crucial for managing transplantation during the pandemic.

Purpose of the Study:

  • To determine the incidence and outcomes of early COVID-19 in KTR within 30 days of transplantation.
  • To compare COVID-19 outcomes in KTR with waitlisted patients.

Main Methods:

  • A retrospective multicenter study involving 12 Indian centers.
  • Analysis of symptomatology, demographics, laboratory findings, and outcomes of COVID-19 in KTR post-transplant.
  • Comparison of outcomes between early COVID-19 KTR, overall KTR, and waitlisted patients.

Main Results:

  • The incidence of early COVID-19 in KTR was 2.6% (22/838 transplants).
  • COVID-19 severity in KTR ranged from asymptomatic (18.2%) to severe (13.6%), with mortality not significantly higher than overall KTR (4.5% vs. 8.5%).
  • Waitlisted patients exhibited significantly higher COVID-19 severity (23.9%) and mortality (15.5%) compared to KTR.

Conclusions:

  • Waitlisted patients have a higher burden of COVID-19 compared to KTR.
  • Early COVID-19 in KTR demonstrates favorable outcomes, suggesting transplantation can continue during the pandemic.
  • This study provides guidance for transplant physicians regarding transplantation decisions in the COVID-19 era.
Abstract

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