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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Pain01:20

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Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Migraine: beyond pain.

Nazia Karsan1, Peter J Goadsby2,3

  • 1NIHR-Welcome Trust King's Clinical Research Facility, SLaM Biomedical Research Centre, King's College London, London, UK nazia.karsan@kcl.ac.uk.

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Summary
This summary is machine-generated.

Migraine is more than just head pain, involving mood, cognition, and sensory changes. Understanding these non-painful symptoms is key to developing better migraine treatments.

Keywords:
headachemigrainepaediatric neurologypain

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Area of Science:

  • Neurology
  • Neuroscience
  • Clinical Medicine

Background:

  • Migraine is a complex neurological disorder often characterized solely by head pain.
  • Current acute treatments primarily target the pain phase of migraine attacks.
  • Migraine's clinical manifestations extend beyond pain, encompassing non-painful symptoms.

Purpose of the Study:

  • To explore the multifaceted nature of migraine beyond head pain.
  • To focus on the non-painful, non-aura symptoms associated with migraine.
  • To highlight the importance of recognizing and studying these additional symptoms.

Main Methods:

  • Review of existing literature on migraine pathophysiology and clinical presentation.
  • Analysis of the broader migraine phenotype, including non-painful features.
  • Emphasis on prospective recording of non-painful symptoms in clinical trials.

Main Results:

  • Migraine involves a spectrum of symptoms including mood, cognitive, and homeostatic alterations.
  • Sensory sensitivities are also prevalent non-painful features of migraine.
  • Existing treatments neglect the significant impact of these non-painful symptoms.

Conclusions:

  • Recognizing the full spectrum of migraine symptoms is crucial for understanding the disorder.
  • Investigating non-painful migraine symptoms offers new pathophysiological and therapeutic insights.
  • Systematic recording of these symptoms can improve patient quality of life.