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Plasma apolipopotein C-2 elevation is associated with Takayasu arteritis
Natsuko Tamura1, Yasuhiro Maejima2, Yuka Shiheido-Watanabe1
1Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Scientific Reports
|September 24, 2021
Summary
Researchers identified apolipoprotein C-2 (ApoC-2) as a potential biomarker for Takayasu arteritis (TAK). Elevated ApoC-2 levels in plasma could aid in diagnosing this autoimmune disease, offering hope for earlier and more accurate detection.
Area of Science:
- Immunology
- Proteomics
- Vascular Biology
Background:
- Takayasu arteritis (TAK) is a rare autoimmune disease affecting large arteries.
- Current diagnostic methods lack specific serological biomarkers, leading to challenges in early detection.
- Identifying novel biomarkers is crucial for improving TAK diagnosis and management.
Purpose of the Study:
- To discover novel serological biomarkers for Takayasu arteritis using an unbiased proteomics approach.
- To identify specific proteins in plasma that are differentially expressed in TAK patients compared to healthy individuals.
- To validate the diagnostic potential of identified proteins for TAK.
Main Methods:
- Plasma samples from untreated TAK patients and healthy controls were analyzed using two-dimensional electrophoresis.
- Differentially expressed protein spots were identified via mass spectrometry (MS/MS).
- Plasma concentrations of candidate proteins were validated using enzyme-linked immunosorbent assay (ELISA).
Main Results:
- Proteomics analysis identified 10 differentially expressed proteins, including apolipoprotein C-2 (ApoC-2).
- ApoC-2 levels were significantly elevated in TAK patients compared to healthy controls.
- ELISA confirmed elevated plasma ApoC-2 as a reliable indicator in TAK.
Conclusions:
- Apolipoprotein C-2 (ApoC-2) is a promising candidate biomarker for the diagnosis of Takayasu arteritis.
- This finding could lead to improved diagnostic strategies for TAK.
- Further research is warranted to confirm ApoC-2's role in clinical practice.
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