Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The embryonic origins of site-specific arthritis.

Nature immunology·2026
Same author

Lymphoid tissue chemokines limit priming duration to preserve CD8<sup>+</sup> T cell functionality.

Science (New York, N.Y.)·2026
Same author

Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches.

Immunity·2026
Same author

Tissue resident memory T cells populate the human uveal tract.

Scientific reports·2026
Same author

Integration of biochemical and physical cues by patrolling CD8<sup>+</sup> T cells.

Trends in immunology·2026
Same author

Lipopolysaccharide confinement in the bacterial outer membrane is governed by interactions within the conserved Lipid A anchor.

The EMBO journal·2026
Same journal

Targeted replacement of human γδ TCR in mice enhances antigen-specific B cell immunity.

Frontiers in immunology·2026
Same journal

Development of bispecific antibodies with enhanced neutralization activity against tested SARS-CoV-2 Omicron subvariants.

Frontiers in immunology·2026
Same journal

Enhancing immunotherapy efficacy in multiple myeloma and chronic lymphocytic leukemia: from combinatorial therapeutic approaches to gut microbiota modulation.

Frontiers in immunology·2026
Same journal

Editorial: Immune-related biomarkers in skin and breast cancer: innovations in immunological diagnostics and therapies.

Frontiers in immunology·2026
Same journal

Case report: Recurrence of anti-myeloperoxidase pauci-immune crescentic glomerulonephritis in a kidney transplant recipient; potential association with HLA antigens and seropositivity?

Frontiers in immunology·2026
Same journal

Case Report: Benralizumab combined with a steroid-sparing strategy in a case of severe eosinophilic granulomatosis with polyangiitis.

Frontiers in immunology·2026
See all related articles

Related Experiment Video

Updated: Oct 19, 2025

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

5.0K

Simulating CXCR5 Dynamics in Complex Tissue Microenvironments.

Jason Cosgrove1,2, Kieran Alden1, Jens V Stein3

  • 1Department of Electronic Engineering, University of York, York, United Kingdom.

Frontiers in Immunology
|September 24, 2021
PubMed
Summary
This summary is machine-generated.

Immune cells use chemokine receptors to navigate tissues. This study shows receptor signaling dynamics, not just numbers, are key for efficient cell migration and antigen scanning in complex environments.

Keywords:
B cellsG-protein coupled receptorschemokinesmathematical modellingsystems biology

More Related Videos

Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation
10:24

Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation

Published on: September 19, 2019

6.5K
Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
14:48

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Published on: April 17, 2021

4.3K

Related Experiment Videos

Last Updated: Oct 19, 2025

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

5.0K
Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation
10:24

Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation

Published on: September 19, 2019

6.5K
Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
14:48

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Published on: April 17, 2021

4.3K

Area of Science:

  • Immunology
  • Computational Biology
  • Cell Biology

Background:

  • Immune cells navigate complex tissue microenvironments by sensing molecular gradients.
  • G-protein coupled receptors (GPCRs) are crucial for this sensing mechanism.
  • Chemokine receptor activity in situ is poorly understood due to receptor complexity and multimodal gradients.

Purpose of the Study:

  • To investigate the spatiotemporal dynamics of CXCR5 expression in a simulated B-follicle.
  • To understand how chemokine receptor activity influences immune cell migration and antigen scanning.
  • To determine the relative importance of receptor numbers versus signaling dynamics in cellular navigation.

Main Methods:

  • Application of a modeling and simulation approach.
  • Analysis of spatiotemporal dynamics of CXCR5 expression at single-cell resolution within an in silico B-follicle.
  • Multi-objective optimization analysis to identify key regulatory factors.

Main Results:

  • In silico B-cell scanning is robust to variations in receptor numbers and individual kinetic rates.
  • Scanning efficiency is sensitive to simultaneous alterations in multiple parameters.
  • Rapid modulation of CXCR5 activity (binding, desensitization, recycling) is essential for optimal antigen scanning.

Conclusions:

  • Chemokine receptor signaling dynamics play a more significant role in regulating migration within complex tissue microenvironments than total receptor numbers.
  • This study provides insights into the mechanisms governing immune cell navigation and positioning.