Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

8.3K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.3K
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

60
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
60
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

75
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
75
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

88
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
88
Methods of reducing fever01:22

Methods of reducing fever

901
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
901
Subviral Agents01:29

Subviral Agents

221
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
221

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical and Radiological Variability in Episodic Ataxia Type 2: A Case Report and Review of the Literature.

Cerebellum (London, England)·2026
Same author

Racial Disparities in People Living with Human Immunodeficiency Virus and Upper Gastrointestinal Bleeding: A Nationwide Study (2016-2021).

Le infezioni in medicina·2026
Same author

Unveiling the Unexpected: Duodenal Ulcer as a Manifestation of Breast Cancer Metastasis.

Journal of community hospital internal medicine perspectives·2026
Same author

Simultaneous Diagnosis of Myasthenia Gravis and Neurosyphilis, With Symptoms Improving After Neurosyphilis Treatment: A Case Report.

Cureus·2026
Same author

The role of chemokines and their receptors in cardiovascular diseases.

Frontiers in immunology·2026
Same author

Intestinal Fatty Acid Binding Protein (I-FABP) in Heart Failure: A Comprehensive Review of its Role as a Biomarker and Mediator in Cardiac Dysfunction.

Current heart failure reports·2026

Related Experiment Video

Updated: Oct 19, 2025

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

809

Crimean-Congo Hemorrhagic Fever Beyond Ribavirin: A Systematic Review.

Stephanie P Fabara1, Juan Fernando Ortiz2,3, Derrick Wayne Smith4

  • 1Internal Medicine, Universidad Catolica de Santiago de Guayaquil, Guayaquil, ECU.

Cureus
|September 24, 2021
PubMed
Summary

Crimean-Congo hemorrhagic fever (CCHF) treatments show promise. Plasma exchange and immunoglobulins reduced mortality, while ribavirin aids post-exposure prophylaxis for this severe tick-borne illness.

Keywords:
crimean congo hemorrhagic feverdexamethasonehyperimmunoglobulinintravenous immunoglobulin (ivig)therapeutic plasmapheresistreatment choices

More Related Videos

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells
10:03

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells

Published on: August 1, 2013

17.2K
High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
11:34

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Published on: May 5, 2014

14.0K

Related Experiment Videos

Last Updated: Oct 19, 2025

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

809
Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells
10:03

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells

Published on: August 1, 2013

17.2K
High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
11:34

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Published on: May 5, 2014

14.0K

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne viral illness.
  • It is endemic across Africa, the Mediterranean, and the Balkans.
  • CCHF has a high case fatality rate, necessitating effective treatments.

Purpose of the Study:

  • To review current literature on treatment and prophylactic measures for CCHF.
  • To identify effective interventions for managing CCHF outbreaks.

Main Methods:

  • Systematic literature search using PubMed and Medical Subject Headings (MeSH).
  • Inclusion of full-text, human studies in English.
  • Analysis of reported treatment outcomes and prophylactic efficacy.

Main Results:

  • Plasma exchange was associated with reduced CCHF mortality.
  • Immunoglobulin therapy effectively decreased disease severity and mortality risk.
  • Ribavirin demonstrated utility as a post-exposure prophylaxis, with no significant route difference.

Conclusions:

  • Supportive care combined with antiviral agents forms the current CCHF management cornerstone.
  • Further research is crucial for definitive therapeutic agents and treatment guidelines.
  • Rising CCHF outbreaks underscore the urgent need for advanced interventions.