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Case Report: Rare Presentation of Mixed Germ Cell Tumor in an Infant
Sriharsha Talluri1, Michael A Goedde1, Susan Coventry2
1Department of Urology, University of Louisville, Louisville, KY, United States.
Insights
Mixed germ cell tumors (MGCT) are rare in prepubertal males, with only one prior report. This case highlights a rare infant MGCT, emphasizing diagnosis and favorable outcomes with management.
Area of Science:
- Pediatric Oncology
- Urologic Oncology
Background:
- Pediatric testis tumors represent 1-2% of childhood cancers, with an incidence of 0.5-2.0 per 100,000 children.
- Mixed germ cell tumors (MGCT) are exceptionally rare in prepubertal males, with limited documented cases.
Observation:
- A case of MGCT in an infant presenting with a painless scrotal mass is reported.
- Differential diagnoses for scrotal masses in prepubertal males include trauma, testis torsion, and hydrocele.
Findings:
- Diagnostic modalities like ultrasonography, CT scans, and tumor markers are crucial for management, mirroring approaches in postpubertal males.
- The infant patient was diagnosed with MGCT confined to the testis post-orchiectomy.
Implications:
- This case contributes to the limited literature on infant MGCT, aiding in understanding this rare condition.
- Prompt diagnosis and appropriate management, including orchiectomy, are associated with favorable prognoses for pediatric testis tumors.
Abstract:
The estimated incidence of pediatric testis tumor is 0.5-2.0 per 100,000 children, accounting for 1-2% of all pediatric tumors. Mixed germ cell tumors (MGCT) in prepubertal males are exceedingly rare, with only one previous case report found in the literature. We report a case of a MGCT in an infant. For prepubertal males, GCTs typically present with a painless scrotal mass, though trauma, testis torsion and hydrocele are also common presentations. Similar to such tumors in postpubertal males, ultrasonography, computed tomography, and tumor markers are integral to determine the best treatment. The patient described in this report presented with a painless scrotal mass. Following orchiectomy, the patient was found to have MGCT that was limited to the testis. With prudent management, these patients tend to have favorable prognoses.
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