Related Experiment Video
Updated: Oct 19, 2025
08:21
A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
5.1K
Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control Study.
Xiaoyu Meng1,2, Huajie Zou1,2, Danpei Li1,2
1Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Frontiers in Public Health
|September 24, 2021
Summary
Elevated angiopoietin-like protein 8 (ANGPTL8) levels are linked to a higher risk of renal dysfunction in the general population. This association was observed across various subgroups, suggesting ANGPTL8
Area of Science:
- Endocrinology and Metabolism
- Nephrology
- Biochemistry
Background:
- Chronic kidney disease (CKD) is a significant global health concern.
- Angiopoietin-like protein 8 (ANGPTL8) influences lipid metabolism and has been implicated in diabetes.
- Previous research indicated elevated ANGPTL8 in diabetic patients, particularly those with albuminuria.
Purpose of the Study:
- To investigate the association between circulating ANGPTL8 levels and kidney function in the general population.
- To determine if ANGPTL8 levels predict the risk of renal dysfunction (RD).
Main Methods:
- A case-control study involving 135 pairs of individuals with renal dysfunction (eGFR <60/min/1.73 m² ) and controls (eGFR ≥ 90 ml/min/1.73 m²).
- Paired t-tests and binary logistic regression analyses were employed.
- Subgroup analyses were conducted for non-diabetic, diabetic, sex, age, BMI, and hyperlipidemia status.
Main Results:
- Circulating ANGPTL8 levels were significantly higher in patients with renal dysfunction compared to controls.
- ANGPTL8 levels showed a negative correlation with estimated glomerular filtration rate (eGFR).
- Elevated ANGPTL8 was independently associated with an increased risk of renal dysfunction, with notable associations in females, older individuals, and those without hyperlipidemia.
Conclusions:
- Elevated serum ANGPTL8 levels are associated with an increased risk of renal dysfunction in the general population.
- The association holds true across diverse subgroups, including diabetic and non-diabetic individuals.
- ANGPTL8 may play a role in the pathophysiology of renal dysfunction.
More Related Videos
Related Concept Videos
01:24Serum Studies: Renal Function Tests
145
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
145
01:17Factors Affecting Renal Clearance: Renal Impairment
204
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
204
01:26Nephrotic Syndrome II : Assessment and Medical Management
38
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
38
01:28Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
30
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
30
01:24Chronic Kidney Disease II: Clinical Manifestations
165
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
165
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
88
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
88