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Related Experiment Video

Updated: Oct 19, 2025

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
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A 3D-Bioprinted Multiple Myeloma Model.

Di Wu1, Zongyi Wang1, Jun Li1

  • 1Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.

Advanced Healthcare Materials
|September 24, 2021
PubMed
Summary
This summary is machine-generated.

A novel 3D bioprinted model mimics the bone marrow microenvironment for multiple myeloma (MM) research. This advanced model improves cell survival and drug response assessment compared to traditional methods.

Keywords:
bioprintingbortezomibcoaxial extrusionmultiple myelomatocilizumab

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Area of Science:

  • Biotechnology
  • Cancer Research
  • Biomedical Engineering

Background:

  • Multiple myeloma (MM) is a plasma cell malignancy comprising 12% of hematological cancers.
  • Current in vitro models often fail to replicate the complex bone marrow microenvironment, impacting research accuracy.

Purpose of the Study:

  • To develop a high-content, 3D in vitro model of multiple myeloma using coaxial extrusion bioprinting.
  • To create a human bone marrow-like microenvironment for improved MM cell culture and drug testing.

Main Methods:

  • Fabrication of a 3D bioprinted model with a mineral-containing sheath and hydrogel core.
  • Co-culture of MM cells with HS5 stromal cells to simulate bone marrow conditions and interleukin-6 (IL-6) release.
  • Investigation of bortezomib efficacy and tocilizumab's role in enhancing chemosensitivity via IL-6 receptor inhibition.

Main Results:

  • The 3D model demonstrated superior MM cell behavior and drug response compared to 2D cultures.
  • Patient-derived MM cells maintained viability for up to 7 days in the 3D model, unlike in planar cultures where they died within 5 days.
  • Tocilizumab showed potential in enhancing bortezomib's efficacy by inhibiting IL-6 receptor.

Conclusions:

  • A 3D bioprinted multiple myeloma model successfully emulates key bone marrow characteristics.
  • This model enhances MM cell proliferation and offers new avenues for drug development and personalized therapy research.
  • The study highlights the potential of bioprinting for creating more physiologically relevant cancer models.