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BASDAI cut-off values corresponding to ASDAS cut-off values.

Oh Chan Kwon1, Min-Chan Park1

  • 1Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Rheumatology (Oxford, England)
|September 24, 2021
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Summary
This summary is machine-generated.

New cut-off values for the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were identified to accurately classify disease activity in axial SpA. These BASDAI values correlate with the Ankylosing Spondylitis Disease Activity Score (ASDAS-CRP), aiding in patient management.

Keywords:
Ankylosing Spondylitis Disease Activity ScoreBASDAIaxial spondyloarthritiscut-off value

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Area of Science:

  • Rheumatology
  • Clinical Assessment
  • Spondyloarthritis

Background:

  • The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS-CRP) are key measures for assessing disease activity in axial spondyloarthritis (axSpA).
  • Establishing precise correlations between these indices is crucial for consistent patient monitoring and treatment decisions.

Purpose of the Study:

  • To determine specific BASDAI cut-off values that effectively discriminate between inactive, moderate, high, and very high disease activity states in axSpA.
  • To validate these BASDAI thresholds against established ASDAS-CRP cut-off values (1.3, 2.1, and 3.5).

Main Methods:

  • A cohort of 333 patients with axSpA was analyzed, utilizing available BASDAI and ASDAS-CRP data.
  • Receiver operating characteristic (ROC) curve analysis was employed to identify optimal BASDAI cut-off points corresponding to ASDAS-CRP thresholds.
  • Weighted kappa statistics were used to assess the agreement between disease activity classifications derived from both indices.

Main Results:

  • The study identified BASDAI values of 1.9, 3.5, and 4.9 as corresponding to ASDAS-CRP values of 1.3, 2.1, and 3.5, respectively.
  • ROC analysis demonstrated high accuracy, with area under the curve (AUC) values ranging from 0.917 to 0.948 for the determined cut-offs.
  • A good level of agreement (weighted kappa: 0.724) was observed between disease activity states classified by BASDAI and ASDAS-CRP.

Conclusions:

  • The BASDAI values of 1.9, 3.5, and 4.9 serve as reliable indicators for inactive, moderate-to-high, and very high disease activity, respectively, in axSpA.
  • These newly defined BASDAI cut-offs provide a practical tool for assessing disease activity, particularly when ASDAS-CRP measurements are not readily available in clinical practice and research settings.