Related Experiment Video
Updated: Oct 19, 2025
07:29
Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure
Published on: August 14, 2017
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Modified Procedures for ALPPS Based on a Risk-Reduced Strategy: Paralleled Clinical Evaluation at Multiple
Ya-Lin Kong1, Ying Xing2, Jie Li3
1Department of Hepatobiliary Surgery, Chinese PLA Air Force Medical Center Affiliated to Air Force Military Medical University, Beijing, China. kjzygdwk@163.com.
Yonsei Medical Journal
|September 24, 2021
Summary
Modified associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) procedures offer improved outcomes for large liver cancer patients. This risk-reduced strategy demonstrates safety and long-term survival, even in cases with insufficient future liver remnant.
Area of Science:
- Hepatobiliary surgery
- Surgical oncology
- Liver regeneration
Background:
- Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a complex procedure for extensive liver tumors.
- Classic ALPPS carries risks, necessitating strategies to improve patient outcomes.
- Assessing modified ALPPS approaches is crucial for managing large liver carcinomas.
Purpose of the Study:
- To compare clinical outcomes of modified ALPPS with classic ALPPS for large liver carcinoma.
- To evaluate the safety and efficacy of a risk-reduced ALPPS strategy.
- To assess the impact on future liver remnant (FLR) and overall survival (OS).
Main Methods:
- Retrospective comparison of 45 patients undergoing modified ALPPS versus 34 patients undergoing classic ALPPS.
- Evaluation of short-term outcomes, FLR and functional FLR (FFLR) increases, and OS.
- Analysis of complications and mortality rates.
Main Results:
- Modified ALPPS showed markedly improved clinical outcomes after the first stage.
- Despite higher rates of liver cirrhosis and hepatocellular carcinoma, mortality and severe complications were not increased.
- Similar FLR and FFLR hypertrophy at 1 week, but lower kinetic growth rates in the modified group.
- Overall survival rates were comparable between the groups.
Conclusions:
- Modified ALPPS procedures are safe for patients with liver cirrhosis and insufficient FLR.
- This risk-reduced strategy supports long-term survival in complex liver cancer cases.
- Modified ALPPS offers a viable alternative for managing large liver tumors.
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