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Updated: Oct 19, 2025
Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis
Published on: January 27, 2023
Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis
Ren-Fei Shan1, Yan-An Zhu, Jie Qin
1Department of Emergency, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, China.
Purpose:
This study aimed to assess the efficacy of traditional Chinese medicine (TCM) in septic patients treated with ulinastatin.
Methods:
PubMed, EmBase, and the Cochrane library were searched up to January 2021 to identify randomized controlled trials. The weight mean difference (WMD) and relative risk (RR) with 95% confidence intervals were used with the random-effects model.
Results:
Twenty-three randomized controlled trials with 1903 septic patients were included. TCM significantly reduced the APACHE II score (WMD: -5.18; P < .001), interleukin-6 (WMD: -63.00; P < .001), tumor necrosis factor-α (WMD: -8.86; P < .001), c-reactive protein (WMD: -9.47; P < .001), mechanical ventilation duration (WMD: -3.98; P < .001), intensive care unit stay (WMD: -4.18; P < .001), procalcitonin (WMD: -0.53; P < .001), lipopolysaccharide (WMD: -9.69; P < .001), B-type natriuretic peptide (WMD: -159.87; P < .001), creatine kinase isoenzyme MB (WMD: -45.67; P < .001), cardiac troponin I (WMD: -0.66; P < .001), and all-cause mortality risk (RR: 0.55; P < .001).
Conclusions:
TCM lowers inflammation levels and reduces the risk of all-cause mortality for septic patients.
