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[COVID-19-induced coagulopathy and thrombosis manifestations]

O Sedlaczek1,2, W Wagner3,4, C E Dempfle5

  • 1Radiology Cooperation Uni/DKFZ, Division of Radiology, NCT, Im Neuenheimer Feld 460, 69120, Heidelberg, Deutschland. o.sedlaczek@med.uni-heidelberg.de.

Der Radiologe
|September 24, 2021
PubMed

Insights

COVID-19 (coronavirus disease 2019) is a systemic disease causing hypercoagulability. Low molecular weight heparins are indicated for hospitalized patients, with radiology crucial for diagnosis and prevention.

Area of Science:

  • Vascular Medicine
  • Infectious Diseases
  • Radiology

Background:

  • COVID-19 (coronavirus disease 2019) presents as a systemic disease with multiorgan involvement.
  • A hypercoagulable state, manifesting as vasculopathy, is a key characteristic of COVID-19.
  • Microstructural vascular changes and diffuse perfusion disorders are significant findings.

Purpose of the Study:

  • To highlight the role of hypercoagulability and vasculopathy in COVID-19.
  • To emphasize the importance of radiological diagnostics in identifying vascular changes.
  • To discuss therapeutic interventions for COVID-19-associated thrombosis.

Main Methods:

  • Radiological diagnosis to identify macrovascular and microvascular pathologies.
  • Assessment of regional hypoperfusion in various organ systems, including the lungs.
  • Review of evidence for antiplatelet drugs and heparins.

Main Results:

  • Radiological findings include macrovascular pathologies and diffuse perfusion disorders.
  • Regional hypoperfusion is detectable in the lungs, with or without pulmonary embolism.
  • Similar vascular findings are observed across multiple organ systems.

Conclusions:

  • Therapeutic intervention with low molecular weight heparins is indicated for hospitalized COVID-19 patients.
  • Extended radiological diagnostics are essential for detecting micro- and macrovascular thrombosis.
  • Radiological findings form the basis for adapted therapy and secondary prevention strategies.
Abstract

Keywords:
CoagulopathyComputedtomographyPerfusionSARS-CoV‑2Treatment

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