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Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
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Iron supplementation for patients undergoing cardiac surgery: a systematic review and meta-analysis of randomized

Stephen Su Yang1,2, Latifa Al Kharusi3, Adam Gosselin3

  • 1Faculty of Medicine, McGill University, Montreal, QC, Canada. stephen.yang@mail.mcgill.ca.

Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|September 24, 2021
PubMed

Insights

This review found that iron supplementation did not significantly reduce red blood cell transfusions in cardiac surgery patients. More research is needed to determine the routine use of iron therapy in this population.

Area of Science:

  • Cardiology
  • Hematology
  • Anesthesiology

Background:

  • Iron supplementation is explored for its potential to improve outcomes in cardiac surgery.
  • Key outcomes include increased hemoglobin and reduced red blood cell transfusion needs.

Purpose of the Study:

  • To evaluate the existing evidence on iron administration in patients undergoing cardiac surgery.
  • To determine the efficacy of iron therapy in reducing transfusion requirements.

Main Methods:

  • A systematic review of randomized controlled trials (RCTs) was conducted.
  • Searches included major databases (MEDLINE, EMBASE, CENTRAL, Web of Science, Google Scholar) up to November 2020.
  • Risk of bias and quality of evidence were assessed using established methodologies.

Main Results:

  • Five RCTs with 554 participants met the inclusion criteria.
  • Iron administration showed no statistically significant difference in transfusion incidence (RR 0.86; 95% CI 0.65-1.13).
  • Trial sequential analysis indicated the need for a larger sample size than accrued.

Conclusions:

  • Current evidence is insufficient to support or refute the routine use of iron therapy in cardiac surgery.
  • Further high-quality RCTs are required to clarify the role of iron supplementation.
Abstract

Keywords:
AnemiaBlood transfusionCardiac surgeryIron

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