Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Molecular Models02:00

Molecular Models

41.8K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
41.8K
Molecular Shapes01:18

Molecular Shapes

59.3K
Molecules have characteristic shapes that are crucial for their function. The arrangement of various electron groups around the central atom dictates their molecular geometry. Electron pairs in the valence shell of a central atom will adopt an arrangement that minimizes repulsions between the electron pairs by maximizing the distance between them. The valence electrons form either bonding pairs, located primarily between bonded atoms, or lone pairs.
Two regions of electron density in a diatomic...
59.3K
Predicting Molecular Geometry02:27

Predicting Molecular Geometry

37.7K
VSEPR Theory for Determination of Electron Pair Geometries
37.7K
Phylogenetic Trees03:21

Phylogenetic Trees

48.2K
Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.
48.2K
Newman Projections02:06

Newman Projections

18.9K
Different notations are used to represent the three-dimensional structure of molecules on two-dimensional surfaces. One of the most commonly used representations is the dash-wedge formula. The dashed wedges, solid wedges, and the plane lines indicate the groups situated behind the plane, coming out of the plane, and in the plane, respectively.
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as...
18.9K
Applications of Molecular Taxonomy01:20

Applications of Molecular Taxonomy

211
Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
211

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mapping Evolution of Molecules across Biochemistry with Assembly Theory.

Journal of chemical information and modeling·2026
Same author

Dimensional Evolution from a Giant Molybdenum-Red Cage-like {Mo<sub>200</sub>} to 1D Chains Enabling Ultrahigh Proton Conduction.

Journal of the American Chemical Society·2026
Same author

Chemputer and chemputation-A universal chemical compound synthesis machine.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Verification and execution of the scientific literature via chemputation augmented by large language models.

Communications chemistry·2026
Same author

Chemical programming of kinase inhibitors in a modular chemputer-based system.

Communications biology·2026
Same author

Spontaneous assemblies of gigantic polyoxomolybdates; from structure and properties to synthetic methods.

Dalton transactions (Cambridge, England : 2003)·2026

Related Experiment Video

Updated: Oct 19, 2025

Interactive Molecular Model Assembly with 3D Printing
06:15

Interactive Molecular Model Assembly with 3D Printing

Published on: August 13, 2020

10.4K

Exploring and mapping chemical space with molecular assembly trees.

Yu Liu1, Cole Mathis1, Michał Dariusz Bajczyk1

  • 1School of Chemistry, University of Glasgow, University Avenue, Glasgow G12 8QQ, UK.

Science Advances
|September 24, 2021
PubMed
Summary

Assembly theory quantifies molecular complexity by the minimum steps to build molecules. This approach reveals new drug candidates not found by traditional methods, showing its potential in drug discovery.

More Related Videos

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

2.8K
Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods
05:34

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Published on: June 6, 2025

989

Related Experiment Videos

Last Updated: Oct 19, 2025

Interactive Molecular Model Assembly with 3D Printing
06:15

Interactive Molecular Model Assembly with 3D Printing

Published on: August 13, 2020

10.4K
Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

2.8K
Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods
05:34

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Published on: June 6, 2025

989

Area of Science:

  • Chemistry
  • Computational Chemistry
  • Drug Discovery

Background:

  • Rule-based chemical space searches yield infinite molecules, necessitating focused exploration.
  • Assembly theory offers a method to assess molecular complexity based on construction steps.

Purpose of the Study:

  • To apply assembly theory to diverse molecular systems, including prebiotic chemistry, gene sequences, plasticizers, and opiates.
  • To explore molecules within an assembly tree framework rather than the entire chemical space.
  • To develop a reassembly method for generating novel molecular candidates.

Main Methods:

  • Utilizing assembly theory to analyze molecular structures based on the minimum steps required for their synthesis.
  • Applying the assembly tree concept to map relationships between molecules.
  • Developing a reassembly technique grounded in assembly trees.

Main Results:

  • The assembly theory approach successfully analyzed molecules across various domains.
  • Exploration was focused on molecules within defined assembly trees.
  • A novel reassembly method generated previously inaccessible opiate drug candidates.

Conclusions:

  • Assembly theory provides a valuable framework for understanding molecular complexity and relationships.
  • The reassembly method based on assembly trees can uncover novel drug candidates beyond conventional approaches.
  • This methodology demonstrates significant potential for applications in drug discovery and molecular design.