Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

1.9K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
1.9K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

11.2K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
11.2K
Disorders of Leukocytes01:27

Disorders of Leukocytes

1.3K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
1.3K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

6.7K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
6.7K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

6.2K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Direct pharmacological targeting of asparagine synthetase to overcome resistance to L-asparaginase in ALL therapy.

JCI insight·2026
Same author

Comparative Study of the Efficacy and Complications of Urethral Realignment and Primary Urethral Anastomosis for Traumatic Urethral Injuries in Emergency Surgical Management.

Archivos espanoles de urologia·2026
Same author

Arthroscopic dual-reduction fixation for acromioclavicular joint dislocation: transosseous and half-cerclage fixation outcomes.

Journal of orthopaedic surgery and research·2026
Same author

Baicalein limits subchondral bone lesions via AMPKα/BECN1 activation in osteoarthritis osteoblast.

International immunopharmacology·2026
Same author

Flow cytometric detection of clonal T-cell populations in CAR T-cell therapy related enteropathy.

Leukemia & lymphoma·2026
Same author

Dual TRBC1-CD3 Immunohistochemistry Shows High Diagnostic Utility in Differentiating Mycosis Fungoides/Sezary Syndrome From Reactive Inflammatory Dermatoses in Skin Biopsies.

The American journal of surgical pathology·2025

Related Experiment Video

Updated: Oct 19, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.3K

Lymphoproliferative Neoplasms With Plasmablastic Morphology.

Jiehao Zhou1, Mehdi Nassiri1

  • 1From the Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis.

Archives of Pathology & Laboratory Medicine
|September 24, 2021
PubMed
Summary

Diagnosing lymphoproliferative neoplasms with plasmablastic morphology can be challenging. Understanding specific disease characteristics and utilizing diagnostic markers like Epstein-Barr virus and human herpesvirus 8 is crucial for accurate identification.

More Related Videos

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

14.6K
Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
08:31

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

350

Related Experiment Videos

Last Updated: Oct 19, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.3K
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

14.6K
Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
08:31

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

350

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Plasmablastic morphology is observed in several rare lymphoproliferative neoplasms.
  • Distinguishing between these neoplasms can be diagnostically challenging.

Purpose of the Study:

  • To review current knowledge of major lymphoproliferative neoplasms exhibiting plasmablastic morphology.
  • To summarize key clinical, morphologic, immunophenotypic, cytogenetic, and molecular features.
  • To provide a practical approach for differential diagnosis.

Main Methods:

  • Comprehensive review of peer-reviewed medical literature.
  • Inclusion of authors' personal clinical experience.

Main Results:

  • Key entities include plasmablastic lymphoma, plasmablastic myeloma, primary effusion lymphoma, human herpesvirus 8-positive diffuse large B-cell lymphoma, and anaplastic lymphoma kinase-positive large B-cell lymphoma.
  • These neoplasms share overlapping features, necessitating detailed analysis.
  • Expression patterns of Epstein-Barr virus-encoded small RNA, human herpesvirus 8, and anaplastic lymphoma kinase are critical diagnostic indicators.

Conclusions:

  • Accurate diagnosis relies on a deep understanding of each disease's phenotype and established criteria.
  • Ancillary studies and clinical context are vital for resolving diagnostic ambiguities.
  • Recognizing specific viral markers and genetic alterations aids in differentiating these entities.