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Cyclodextrins-modified metallic nanoparticles for effective cancer therapy
1Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM'S NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai, India.
Summary
Metallic nanoparticles complexed with cyclodextrins offer a novel approach to cancer therapy, overcoming chemotherapy
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Chemotherapy faces limitations including severe systemic toxicities and poor drug delivery efficiency.
- Conventional chemotherapeutics often exhibit poor solubility, in-vivo instability, and lack of targeting.
- Cancer remains a leading cause of death worldwide, necessitating improved treatment strategies.
Purpose of the Study:
- To review metallic nanocarriers for enhanced cancer therapy.
- To explore cyclodextrin-complexed metallic nanoparticles as a novel drug delivery platform.
- To address the limitations of conventional chemotherapy.
Main Methods:
- Encapsulation of hydrophobic anti-cancer drugs within cyclodextrins.
- Development of metallic nanoparticles (gold, silver, magnetic metal oxides) as drug carriers.
- Utilizing external triggers like NIR or magnetic fields for controlled drug release.
Main Results:
- Metallic nanoparticles improve drug solubility, stability, and targeting efficiency.
- Cyclodextrin complexation enhances drug loading capacity and in-vivo stability.
- Externally triggered drug release optimizes therapeutic kinetics.
Conclusions:
- Cyclodextrin-complexed metallic nanoparticles represent a promising platform for effective cancer therapy.
- This approach minimizes systemic toxicities associated with conventional chemotherapy.
- The novel strategy holds significant potential for clinical applications in cancer diagnosis and treatment.
