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Biocide resistance in Acinetobacter baumannii: appraising the mechanisms
E S Milani1, A Hasani2, M Varschochi3
1Infectious and Tropical Diseases Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
The Journal of Hospital Infection
|September 24, 2021
Summary
Antibiotic-resistant Acinetobacter baumannii infections are rising globally. Proper biocide use is crucial to prevent resistance and control hospital-acquired infections, guiding new agent discovery.
Area of Science:
- Microbiology
- Infectious Diseases
- Public Health
Background:
- Acinetobacter baumannii is a significant cause of hospital-acquired infections.
- Global rise in antibiotic-resistant strains necessitates improved infection control strategies.
- Inappropriate biocide use can inadvertently promote antimicrobial resistance.
Purpose of the Study:
- To review the mechanisms of action of biocides against Acinetobacter baumannii.
- To explore bacterial resistance mechanisms to biocidal agents.
- To discuss methods for assessing biocide susceptibility and resistance.
Main Methods:
- Literature review of scientific publications on biocides, disinfectants, and Acinetobacter baumannii.
- Analysis of mechanisms of biocide action and bacterial resistance pathways.
- Examination of current approaches for antimicrobial susceptibility testing.
Main Results:
- Biocides can induce stress responses in bacteria, potentially leading to resistance.
- Sub-lethal biocide concentrations are a key factor in promoting resistance.
- Understanding resistance mechanisms is vital for developing effective biocides.
Conclusions:
- Strategic selection and application of biocides are essential for managing Acinetobacter baumannii.
- Effective bio-contamination management plans must consider biocide efficacy and resistance.
- Further research into novel biocidal agents and resistance modulation is warranted.
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