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Detection of transdermal biomarkers using gradient-based colorimetric array sensor.

Jingjing Yu1, Di Wang2, Vishal Varun Tipparaju3

  • 1Center for Bioelectronics and Biosensors, The Biodesign Institute, Arizona State University, USA; Department of Electrical Engineering and Computer Science, South Dakota State University, Brookings, SD, 57007, USA.

Biosensors & Bioelectronics
|September 24, 2021
PubMed
Summary
This summary is machine-generated.

A new wearable sensor system noninvasively monitors dietary macronutrient intake by detecting transdermal volatile biomarkers. This technology offers a low-cost, accurate method for disease and weight management outside clinical settings.

Keywords:
Breath biomarkersColorimetric sensorDietary macronutrients intakeTransdermal volatile biomarkersWearable device

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Wearable Technology

Background:

  • Accurate dietary macronutrient assessment is vital for managing chronic diseases like obesity, diabetes, and cardiovascular disease.
  • Conventional methods (self-reporting, blood/breath analysis) have limitations including burden, inaccuracy, invasiveness, and potential for human error.
  • There is a need for noninvasive, accurate, and user-friendly tools for real-time dietary intake monitoring.

Purpose of the Study:

  • To develop and validate a wearable transdermal volatile biomarker detection system for assessing dietary macronutrient intake.
  • To utilize novel colorimetric sensing technology for quantifying transdermal biomarkers.
  • To provide a noninvasive alternative to existing dietary assessment methods.

Main Methods:

  • A wearable system employing a gradient-based colorimetric array sensor (GCAS) was developed.
  • The GCAS quantifies transdermal volatile biomarker emission rates by tracking color changes via an optical system and image processing.
  • The system was tested for transdermal acetone detection in subjects on a ketogenic diet, correlating results with breath acetone levels.

Main Results:

  • The GCAS system successfully detected increased transdermal acetone levels following ketogenic diets and decreases after carbohydrate-rich diets.
  • A strong correlation (R² = 0.8877) was observed between GCAS transdermal acetone measurements and breath acetone concentration (0-40 ppm).
  • The system demonstrated capability for simultaneous, multiplexed detection of multiple analytes.

Conclusions:

  • The developed wearable GCAS system offers a noninvasive, low-cost, and wearable solution for assessing dietary macronutrient intake.
  • This technology has significant potential for applications in disease management, weight control, and personalized nutrition.
  • The findings support the use of transdermal volatile biomarkers for real-time dietary monitoring outside traditional healthcare settings.