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Updated: Oct 19, 2025

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
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Regulatory interplay between microRNAs and WNT pathway in glioma

Peyman Tabnak1, Asrin Mafakheri2, Zanyar Haji Emsailpoor1

  • 1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|September 24, 2021
PubMed

Insights

This review explores microRNAs (miRNAs) and their role in the WNT pathway in glioma, a challenging brain cancer. Understanding this interplay offers new therapeutic strategies for glioma treatment.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Cancer Genetics

Background:

  • Glioma, a prevalent central nervous system neoplasm, exhibits poor patient survival rates.
  • Identifying molecular mechanisms driving glioma malignancy is crucial due to treatment challenges.
  • Altered microRNA (miRNA) expression is a hallmark of many cancers, including glioma.

Purpose of the Study:

  • To comprehensively review microRNAs (miRNAs) involved in the WNT pathway in glioma.
  • To elucidate the interplay between miRNAs and the WNT pathway in glioma progression.
  • To highlight potential therapeutic targets based on miRNA-WNT pathway interactions.

Main Methods:

  • Literature review of studies on miRNAs, WNT pathway, and glioma.
  • Analysis of miRNA involvement in key cancer processes within glioma.
  • Examination of therapeutic strategies targeting the miRNA-WNT axis.

Main Results:

  • MicroRNAs (miRNAs) significantly influence WNT pathway activity in glioma.
  • The interplay between miRNAs and WNT signaling regulates glioma proliferation, invasion, migration, and treatment resistance.
  • Specific miRNAs and WNT pathway components are implicated in epithelial-mesenchymal transition in glioma.

Conclusions:

  • The intricate relationship between miRNAs and the WNT pathway is central to glioma pathogenesis.
  • Targeting this miRNA-WNT axis presents promising avenues for novel glioma therapies.
  • Further research into these interactions could lead to improved treatment outcomes for glioma patients.
Keywords:
GliomaWNTcircRNAlncRNAmiRNA

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