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Stereotactic Radiosurgery for Gynecologic Cancer
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Intensity modulated high dose rate ocular brachytherapy using Se-75.

Justine M Dupere1, John J Munro2, David C Medich1

  • 1Worcester Polytechnic Institute, MA.

Brachytherapy
|September 25, 2021
PubMed
Summary

This study introduces a novel approach for ocular melanoma treatment using Selenium-75 (Se-75) high-dose-rate brachytherapy with a gold shielded ring applicator. Computational modeling shows this method delivers appropriate ocular dose distributions, potentially improving treatment efficiency and safety.

Keywords:
COMSChoroidal melanomaDose calculationsEye plaqueHDRIntensity modulatedMCNPOcular brachytherapySe-75

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Ophthalmology

Background:

  • Ocular melanomas are traditionally treated with low-dose-rate (LDR) brachytherapy.
  • There is a need for advanced brachytherapy techniques offering improved dose conformity and reduced treatment times.

Purpose of the Study:

  • To computationally evaluate a novel brachytherapy approach for ocular melanomas.
  • To investigate the use of a gold shielded ring applicator with a Selenium-75 (Se-75) high-dose-rate (HDR) source for intensity modulation.

Main Methods:

  • Computational modeling using MCNP6 simulations.
  • Design of a gold shielded ring applicator with adjustable collimation for Se-75 sources.
  • Dosimetric calculations for various applicator, collimator, and target sizes.

Main Results:

  • The Se-75 ring source delivered prescription doses to target apex depths of 3.5-8 mm for tumors 10-15 mm in diameter.
  • Specific dose rates to critical structures were calculated, with the tumor receiving the highest dose.
  • Dose distributions were found to be appropriate for ocular brachytherapy.

Conclusions:

  • The proposed Se-75 HDR brachytherapy with a gold shielded ring applicator is suitable for ocular melanoma treatment.
  • The collimator design allows for better dose conformity to the tumor volume.
  • This method offers reduced treatment time, lower costs, and enhanced surgeon safety via remote afterloading.