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Bioengineering Approaches for the Advanced Organoid Research.
Sang Ah Yi1,2, Yixiao Zhang2, Christopher Rathnam2
1Epigenome Dynamics Control Research Center, School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, 16419, Republic of Korea.
Advanced Materials (Deerfield Beach, Fla.)
|September 25, 2021
Summary
Scientists are engineering advanced organoids using 3D cell culture and biomaterials. These stem cell-derived organoids mimic native organs, paving the way for better disease modeling and therapeutics.
Area of Science:
- Biotechnology
- Stem Cell Biology
- Tissue Engineering
Background:
- 3D cell culture and stem cell-derived organoids recapitulate native organ structure and function.
- Organoid development relies on understanding physical cues and biochemical signaling.
- Reproducible organoids require dynamic niches mimicking in vivo organogenesis.
Purpose of the Study:
- To summarize recent advances in organoid engineering.
- To identify critical parameters for organ-specific patterning.
- To discuss future trends in tunable organoid development.
Main Methods:
- Incorporation of innovative biomaterial-based and advanced engineering approaches.
- Utilizing extracellular matrices and genetic modulation for organoid engineering.
- Developing dynamic niches for controlled organoid development.
Main Results:
- Organoid technologies are advancing towards precise control over development.
- Biomaterials and engineering enhance organoid culture reproducibility.
- Key parameters for organ-specific patterning are being identified.
Conclusions:
- Organoid engineering is crucial for next-generation developmental studies.
- Tunable organoids offer promise for disease modeling and therapeutics.
- Advanced organoid culture methods are essential for future research.
