Related Experiment Video
Updated: Oct 19, 2025
09:11
Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
683
Relapsing polychondritis after treatment with PD-1 blockade
Tatsuya Ogimoto1, Hironori Yoshida2, Masanobu Mizuta3
1Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Investigational New Drugs
|September 25, 2021
Summary
Nivolumab, a cancer drug, can trigger relapsing polychondritis (RP), a rare cartilage inflammation. This immune-related adverse event (irAE) requires physician awareness for prompt management.
Area of Science:
- Immunology
- Oncology
- Rheumatology
Background:
- Nivolumab is an immune checkpoint inhibitor targeting programmed death 1 (PD-1).
- Immune-related adverse events (irAEs) are known complications of PD-1 blockade therapy.
- Relapsing polychondritis (RP) is a rare autoimmune condition characterized by cartilage inflammation.
Observation:
- A 72-year-old patient with mandibular cancer developed exertional dyspnea and cough during nivolumab treatment and prednisolone (PSL) tapering.
- The patient had undergone surgery for mandibular cancer and radiation therapy for lung metastases.
- No deterioration in mandibular cancer or radiation pneumonitis was noted.
Findings:
- Fluorodeoxyglucose (FDG)-PET/CT revealed thickening and abnormal FDG uptake in tracheobronchial and nasal septum cartilage.
- These findings were absent prior to nivolumab initiation.
- The clinical presentation and imaging findings led to a diagnosis of nivolumab-induced RP.
Implications:
- Relapsing polychondritis can manifest as an immune-related adverse event of nivolumab therapy.
- Early recognition and management of nivolumab-induced RP are crucial to prevent severe respiratory complications.
- Physicians should consider RP in patients on nivolumab presenting with relevant symptoms.
Related Concept Videos
01:20COPD: Pathogenesis and Clinical Features
700
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
700
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
3.0K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.0K
01:23Rheumatic Heart Disease I: Introduction
102
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
102
01:17Pericarditis III: Medical Management
62
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
62
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
3.3K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
3.3K
01:22Chronic Obstructive Pulmonary Disease
1.6K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.6K