Related Experiment Video
Updated: Oct 19, 2025

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
Efficacy of non-pharmacological interventions in patients with overactive bladder: A protocol for systematic review
Hong Zhou1, Wenzhen Chen2, Yunzhu Yan3
1Wuhan No.1 Hospital, Wuhan, China.
Background:
Some meta-analyses have proved the superiority of non-pharmacological interventions in overactive bladder (OAB), but the best choice is still controversial.
Aim:
To assess the most effective interventions in female with OAB.
Methods:
Studies for relevant randomized controlled trials which compare different kinds of non-pharmacological interventions in females with OAB will be retrieved from 8 databases including PubMed, Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure, Wanfang Database, VIP Database and China Biology Medicine disc, from inception to 1 January 2021. After screening titles and abstracts, detailed data including participates, interventions and outcomes will be extracted according to the eligible criteria. Then, Cochrane risk-of-bias tool will be used to assess the quality of the literature. The pairwise meta-analysis will be conducted by STATA. Network meta-analysis will be performed to compare and rank the effects of different non-pharmacological interventions, in terms of alleviation of symptoms, by OpenBUGS, R and STATA.
Results:
This network meta-analysis will present the best available evidence about non-pharmacological interventions for OAB to both relieve symptoms and improve life quality.
Related Concept Videos
Urodynamic Studies: Uroflowmetry
Urinary Tract Calculi III: Medical Management
Urinary Tract Calculi V: Nursing Management
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
Urinary Tract Infection IV: Nursing Management
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...

