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Tackling PARP inhibitor resistance

Kasper Fugger1, Graeme Hewitt1, Stephen C West1

  • 1The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

Trends in Cancer
|September 26, 2021
PubMed
Summary

Homologous recombination-deficient (HRD) tumors show sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPis). Genetic screens reveal new targets to overcome PARPi resistance in HRD cancers.

Keywords:
base excision repairhomologous recombination repairnucleotide metabolismpoly(ADP-ribose) polymerase inhibitorstherapy resistance

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