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TBK1 has a new Akt.

Leslie M Shaw1

  • 1Department of Molecular, Cell & Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.

The Journal of Biological Chemistry
|September 26, 2021
PubMed
Summary

TANK-binding kinase 1 (TBK1) regulates cellular metabolism and growth. TBK1 activates Akt via mTORC2, revealing its role in responding to environmental signals.

Area of Science:

  • Immunology
  • Cellular Metabolism
  • Signal Transduction

Background:

  • TANK-binding kinase 1 (TBK1) is crucial for innate immunity against pathogens.
  • Emerging evidence suggests TBK1 also regulates cellular metabolism, but mechanisms remain unclear.

Purpose of the Study:

  • To elucidate the mechanisms by which TBK1 regulates cellular metabolism and growth.
  • To investigate the role of TBK1 in integrating environmental signals for metabolic control.

Main Methods:

  • Investigated TBK1-mediated signaling pathways.
  • Utilized biochemical assays to assess kinase activity and protein interactions.
  • Examined the impact of TBK1 on cellular growth and metabolic parameters.

Main Results:

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  • Demonstrated that TBK1 activates the downstream kinase Akt.
  • Showed that this activation is dependent on the mechanistic target of rapamycin complex 2 (mTORC2).
  • Identified a novel signaling axis linking TBK1, mTORC2, and Akt in metabolic regulation.

Conclusions:

  • TBK1 plays a significant role in regulating cellular metabolism and growth.
  • The TBK1-mTORC2-Akt pathway is a key mechanism for controlling cellular responses to environmental inputs.
  • This finding expands the known functions of TBK1 beyond innate immunity.