A hitchhiker's guide through the COVID-19 galaxy

Area of Science:

• Immunology
• Infectious Diseases
• Pharmacology

Background:

• Coronavirus disease 2019 (COVID-19) reviews often lack practical treatment guidance.
• A gap exists in linking COVID-19 immunopathology to clinical treatment decisions.
• Understanding the host response is crucial for effective patient management.

Purpose of the Study:

• To provide a practical guide on COVID-19 treatment selection.
• To integrate immunopathology knowledge with therapeutic options.
• To support frontline clinicians in tailoring treatments to patient status.

Main Methods:

• Literature review synthesizing current knowledge on COVID-19 immunopathology.
• Analysis of published evidence for available and emerging treatment options.
• Focus on linking immunological background to clinical decision-making.

Main Results:

• The review combines immunopathology insights with treatment evidence.
• It addresses the "how to treat whom with what and when" question.
• It acknowledges the rapidly evolving nature of COVID-19 information.

Conclusions:

• This guide aims to enhance understanding of host response in COVID-19.
• It supports clinicians in selecting optimal treatments.
• It provides a framework for evidence-based COVID-19 management.