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Methylphenidate may improve mental fatigue in individuals with multiple sclerosis: A pilot clinical trial
J Y Natsheh1, J DeLuca2, S L Costa2
1Kessler Foundation, 120 Eagle Rock Ave, Suite 100, East Hanover, NJ 07936, USA; Children's Specialized Hospital Research Center, New Brunswick, NJ, USA; Departments of Physical Medicine and Rehabilitation; and Neurology, Rutgers, New Jersey Medical School, Newark, NJ, USA; Palestinian Neuroscience Initiative, Al-Quds University, Jerusalem, Palestine.
Background:
Fatigue is the most common symptom in multiple sclerosis (MS), previously attributed to dopamine imbalance. Evidence suggests that methylphenidate, a psychostimulant that increases striatal and prefrontal dopamine levels, is effective in reducing fatigue in various disorders. However, its effect on state vs. trait mental fatigue in MS is yet to be examined.
Methods:
This pilot study investigates the efficacy of methylphenidate on decreasing self-reported mental fatigue in 12 individuals with MS in a double-blind, placebo-controlled, cross-over randomized clinical trial.
Results:
Our results show that "state", but not "trait" MS-related fatigue, was reduced after 4 weeks of methylphenidate administration as compared to placebo.
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