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Modeling Intraperitoneal Insulin Absorption in Patients with Type 1 Diabetes
Michele Schiavon1, Claudio Cobelli2, Chiara Dalla Man1
1Department of Information Engineering, University of Padova, 35131 Padova, Italy.
Metabolites
|September 26, 2021
Summary
A new mathematical model describes insulin absorption and distribution after intraperitoneal (IP) administration in type 1 diabetes (T1D) patients. This model enhances understanding of IP insulin therapy, offering potential for improved glucose control.
Area of Science:
- Biomedical Engineering
- Pharmacokinetics
- Diabetes Mellitus Research
Background:
- Subcutaneous (SC) insulin delivery for type 1 diabetes (T1D) faces challenges with absorption delays and variability.
- Intraperitoneal (IP) insulin administration presents a viable alternative to SC delivery, despite its invasiveness.
Purpose of the Study:
- To develop and validate a mathematical model for insulin absorption and distribution following IP administration in T1D patients.
- To address the lack of existing pharmacokinetic models for IP insulin delivery.
Main Methods:
- Utilized data from eight T1D patients receiving IP insulin via implanted pumps, with frequent plasma insulin and glucose measurements.
- Tested and compared various models to describe IP insulin kinetics.
- Selected the best-fitting model based on predictive accuracy, parameter precision, and parsimony.
Main Results:
- A two-compartment model for IP insulin absorption was identified.
- A coupled two-compartment whole-body insulin kinetics model, including hepatic insulin extraction, was established.
- The model successfully described insulin absorption and distribution from the IP space.
Conclusions:
- The developed model provides a quantitative description of IP insulin pharmacokinetics.
- This model is a crucial step towards integrating IP insulin delivery into advanced diabetes management systems, such as the UVa/Padova T1D Simulator.
- Future work will focus on incorporating this model for simulating IP insulin-based therapies.
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