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Adipose Tissue and Biological Factors. Possible Link between Lymphatic System Dysfunction and Obesity
Klaudia Antoniak1, Rita Hansdorfer-Korzon2, Małgorzata Mrugacz3
1Department of Immunobiology and Environment Microbiology, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland.
Metabolites
|September 26, 2021
Summary
Obesity impairs lymphatic system function, potentially contributing to its own development. This review explores obesity-related lymphatic dysfunction and therapeutic strategies.
Area of Science:
- Medical Science
- Physiology
- Metabolic Disorders
Background:
- Obesity is a major global health threat, linked to numerous chronic diseases.
- It involves increased adipose tissue and altered metabolite release.
- Obesity is associated with metabolic syndrome, type 2 diabetes, insulin resistance, cardiovascular disease, and cancer.
Purpose of the Study:
- To review current findings on obesity-related lymphatic system dysfunction.
- To explore the role of biological factors in lymphatic pathophysiology during obesity.
- To propose potential therapies targeting lymphatic function in obesity.
Main Methods:
- Literature review of clinical and experimental studies.
- Analysis of biological factors involved in lymphatic system function.
- Discussion of therapeutic interventions for lymphatic support.
Main Results:
- Obesity significantly impairs lymphatic system function.
- Lymphatic dysfunction may play a role in obesity pathogenesis.
- Specific biological factors contribute to these pathophysiological changes.
Conclusions:
- There is a bidirectional relationship between obesity and lymphatic dysfunction.
- Understanding these mechanisms can inform new therapeutic approaches.
- Targeting lymphatic system support may offer novel obesity treatments.
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