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Biological functions and potential therapeutic applications of huntingtin-associated protein 1: progress and

X Zhao1, A Chen1,2, Z Wang1

  • 1School of Medical Laboratory, Weifang Medical University, Weifang, Shandong, 261053, People's Republic of China.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|September 26, 2021
PubMed

Insights

Huntingtin-associated protein 1 (HAP1) interacts with huntingtin (HTT), a protein linked to Huntington disease (HD). Research on HAP1 function offers insights into neurodegenerative diseases, endocrine disorders, and cancer, potentially revealing new therapeutic targets.

Area of Science:

  • Neuroscience
  • Genetics
  • Oncology

Background:

  • Huntington disease (HD) is a neurodegenerative disorder caused by polyglutamine expansion in the huntingtin (HTT) protein.
  • Huntingtin-associated protein 1 (HAP1) is a known interacting partner of HTT and is implicated in HD pathogenesis.
  • HAP1 expression extends beyond the nervous system to the endocrine and digestive systems, suggesting broader disease relevance.

Purpose of the Study:

  • To summarize recent research advancements on the role of HAP1 in various diseases.
  • To elucidate the functions of HAP1 and its interacting proteins.
  • To identify potential new therapeutic targets for cancer and related conditions.

Main Methods:

  • Literature review of recent studies on HAP1.
  • Analysis of HAP1's interactions with HTT and other proteins.
  • Exploration of HAP1's involvement in nervous, endocrine, and digestive system diseases.

Main Results:

  • HAP1 plays a significant role in the nervous system, particularly in relation to Huntington disease.
  • HAP1 is involved in the pathogenesis of endocrine and digestive diseases, as well as cancer.
  • Understanding HAP1's interactions is crucial for deciphering HTT's role in disease.

Conclusions:

  • HAP1 is a key protein with diverse roles in neurodegeneration, endocrine disorders, and cancer.
  • Further research into HAP1 functions and interactions can yield novel therapeutic strategies.
  • HAP1 represents a promising target for developing treatments for a range of diseases.

Keywords:
CancersHAP1HuntingtinHuntington diseaseTumor suppressor

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